EMSE is a suite of advanced, powerful, and useable softwEMSEBannerare tools to measure, describe, and visualize human brain dynamics, used worldwide for research in neuroscience, neurotechnology, and clinical neurophysiology. We specialize in multimodal source estimation techniques, enabling the researcher to combine EEG and MRI datasets to better answer where things are happening in the brain, and when things change.

Conventional neuroimaging (for example magnetic resonance imaging, or MRI) can answer the where question, but not the when question. Electroencephalography (EEG) and the closely allied Event-Related Potentials (ERP’s) can tell you when something happened with an accuracy of thousandths of a second, but isn’t very good at the where questions. EMSE combines MRI and EEG to answer both when and where in a way that neither method can answer alone. We call this process multimodal dynamic functional brain imaging or source estimation.

Our principal product is EMSE® Suite, a software toolkit consisting of 6 modules. The modules may be purchased separately, or as a bundle. Taken together, EMSE® Suite supports the key steps required to combine electrophysiological data (like EEG and MEG) with image data (like CT or MRI) for multimodal dynamic functional imaging. Taken separately, individual modules may be used by customers who wish only a subset of the complete functionality (e.g. EEG time series analysis and display). EMSE® Suite runs under the Microsoft Windows family of operating systems as well as Linux, on Intel- compatible processors.

EMSE Modules

Digitizing electrode positions in Locator.


When used together with Polhemus™ digitizing hardware, LOCATOR allows you to measure accurately electrode locations and the outer head surface in 3 dimensions. These data may then be used for MRI coregistration and more accurate source estimation. LOCATOR currently supports three Polhemus products: ISOTRAK, FASTRAK, and PATRIOT.

Sample functionality in Data Editor.

Data Editor

The EMSE Suite DATA EDITOR module may be used as a standalone program to view, analyze, filter, and transform EEG and MEG time series data, and to select intervals or events for further analyses, including event-related potentials, power spectral densities, and time-frequency analysis.  DATA EDITOR includes tools for automation, signal processing, spatial component analysis, topographic mapping, and a powerful framework for statistical nonparametric mapping.

Sample functionality in Source Estimator.

Source Estimator

EMSE Suite SOURCE ESTIMATOR module may be used for discrete or distributed dipole source analysis from EEG or MEG data which has been provided by the DATA EDITOR module. Three shell spherical models or realistic head models (using data from the IMAGE PROCESSOR module) may be used for field calculations.  3D source estimates may be displayed in VISUALIZER for rendering with surfaces or in MR VIEWER with MRI overlay.

Sample MR Viewer functionality.

MR Viewer

MR VIEWER displays magnetic resonance and other images, with specialized features designed for the overlay of electromagnetic source estimation and other functional imaging data. Seeded dipoles may be obtained (e.g. from fMRI data) for use with SOURCE ESTIMATOR

Sample functionality from Image Processor.

Image Processor

Starting with a volumetric dataset from the MR VIEWER base module, IMAGE PROCESSOR tools support segmentation, boundary mesh generation, and cortical unfolding. The output may be made available to VISUALIZER for 3D rendering, or to SOURCE ESTIMATOR for realistic headshape modeling and cortical surface restriction.

Sample functionality in Visualizer.


Use VISUALIZER to obtain and view 3D rendered images, combining data from several modalities, including topographic mapping, MRI data and electromagnetic source analysis.